TT virus loads and lymphocyte subpopulations in children with acute respiratory diseases.
نویسندگان
چکیده
TT virus (TTV) produces chronic plasma viremia in around 90% of healthy individuals of all ages and has, therefore, been proposed as a commensal human virus. We recently demonstrated that in children hospitalized for acute respiratory diseases high TTV loads were associated with severe forms of disease. Here, we report that in such children TTV loads showed an inverse correlation with the percentage of circulating total T and helper T cells and a direct correlation with the percentage of B cells. Thus, florid TTV replication might contribute to lymphocyte imbalances and, possibly, immunosuppressive effects, thus resembling related animal viruses.
منابع مشابه
TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity.
The natural history and pathogenic potential of the recently identified TT virus (TTV) are currently a matter of intensive investigation. In an attempt to shed some light on these issues, nasal and blood specimens of 1- to 24-month-old children hospitalized with a clinical diagnosis of acute respiratory disease (ARD) were examined for the presence, load, and genetic characteristics of TTV. The ...
متن کاملALTERATION OF T-LYMPHOCYTE SUBPOPULATIONS IN SUBACUTE AND CHRONIC BRUCELLOSIS
Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations...
متن کاملInfluenza A virus among the hospitalized young children with acute respiratory infection. Is influenza A co infected with respiratory syncytial virus?
Background: Both influenza A virus (IAV) and respiratory syncytial virus (RSV) cause acute respiratory infection (ARI) in infants and young children. This study was conducted to determine Influenza A virus and its co infection with RSV among the hospitalized children with ARI. Methods: A total of 153 throat samples of the hospitalized young children aged between below one year and 5 years with...
متن کاملنقش ویروس های سن سی شیال تنفسی و آنفلوآنزا در عفونت های حاد مجاری تنفسی تحتانی کودکان استان مازندران در سال 1381
Background and purpose: The acute lower respiratory tract infective agents in children are different. The rate of their role in causing infection differs with the age of patients, season, geographical areas and diagnostic methods. The aim of this study is to determine the rate of the role of respiratory syncytial and influenza viruses in Mazandaranian children infected with acute lower res...
متن کاملتعیین فراوانی عفونت ویروسی پاراآنفلوآنزا به روش ایمونوفلوئورسانس در عفونتهای حاد تنفسی
Background: Acute respiratory tract infections, both bacterial and viral, cause 4.5 million childhood deaths worldwide, most of which occur in developing countries. Parainfluenza viruses, of the paramyxoviridae family, are among the common causes of acute respiratory infections, giving rise to 30% of respiratory infections in children before school age. The four parainfluenza viruses that cause...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of virology
دوره 77 16 شماره
صفحات -
تاریخ انتشار 2003