TT virus loads and lymphocyte subpopulations in children with acute respiratory diseases.

نویسندگان

  • Fabrizio Maggi
  • Massimo Pifferi
  • Elena Tempestini
  • Claudia Fornai
  • Letizia Lanini
  • Elisabetta Andreoli
  • Marialinda Vatteroni
  • Silvano Presciuttini
  • Angelo Pietrobelli
  • Attilio Boner
  • Mauro Pistello
  • Mauro Bendinelli
چکیده

TT virus (TTV) produces chronic plasma viremia in around 90% of healthy individuals of all ages and has, therefore, been proposed as a commensal human virus. We recently demonstrated that in children hospitalized for acute respiratory diseases high TTV loads were associated with severe forms of disease. Here, we report that in such children TTV loads showed an inverse correlation with the percentage of circulating total T and helper T cells and a direct correlation with the percentage of B cells. Thus, florid TTV replication might contribute to lymphocyte imbalances and, possibly, immunosuppressive effects, thus resembling related animal viruses.

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عنوان ژورنال:
  • Journal of virology

دوره 77 16  شماره 

صفحات  -

تاریخ انتشار 2003